Global variation in CYP2C8–CYP2C9 functional haplotypes
نویسندگان
چکیده
منابع مشابه
Global Properties and Functional Complexity of Human Gene Regulatory Variation
Identification and functional interpretation of gene regulatory variants is a major focus of modern genomics. The application of genetic mapping to molecular and cellular traits has enabled the detection of regulatory variation on genome-wide scales and revealed an enormous diversity of regulatory architecture in humans and other species. In this review I summarise the insights gained and quest...
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Regulatory cis-acting variants account for a large proportion of gene expression variability in populations. Cis-acting differences can be specifically measured by comparing relative levels of allelic transcripts within a sample. Allelic expression (AE) mapping for cis-regulatory variant discovery has been hindered by the requirements of having informative or heterozygous single nucleotide poly...
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The adiponectin gene (ADIPOQ) plays an important role in energy homeostasis. In this study five separate regions (regions 1 to 5) of ovine ADIPOQ were analysed using PCR-SSCP. Four different PCR-SSCP patterns (A₁-D₁, A₂-D₂) were detected in region-1 and region-2, respectively, with seven and six SNPs being revealed. In region-3, three different patterns (A₃-C₃) and three SNPs were observed. Two...
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Motivation Current statistical models of haplotypes are limited to panels of haplotypes whose genetic variation can be represented by arrays of values at linearly ordered bi- or multiallelic loci. These methods cannot model structural variants or variants that nest or overlap. Results A variation graph is a mathematical structure that can encode arbitrarily complex genetic variation. We prese...
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The working draft of a reference sequence of the human genome is nearing completion and is providing a basis for studies in a variety of domains. Computational challenges exist in all of these domains because of the massive amounts of data, the multiple often complex relationships among the types of relevant data, and the need to make the data accessible to researchers approaching the data from...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2009
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2009.10